Why Everyone Needs MaxGXL™ Capsules

http://www.maxgxl.com/radkins

http://www.maxgxl.com/radkins

Why Everyone Needs MaxGXL™ Capsules

This article will demonstrate to you why Glutathione is so important to your health and well-being.

Glutathione (pronounced 'gloota-thigh-own') is the body's essential health ABC's - Antioxidant, Blood Booster and Cell Detoxifer.

It is a tripeptide composed of glutamic, cysteine and glycine. Glutathione is found in all cells in the body, including the bile, the epithelial lining fluid of the lungs, and - at much smaller concentrations - in the blood.

Glutathione is the smallest intracellular non-protein thiol (molecule containing an S_H or sulfhydryl group) molecule in the cells. This characteristic emphasizes its potent antioxidant action and supports a multifaceted thiol exchange system, which regulates cell activity.

This small protein, produced naturally in the body, maintains these three crucial protective functions. In fact, your life depends on glutathione. Without it, your cells would disintegrate from unrestrained oxidation, your body would have little resistance to metabolic acids, and your liver would shrivel up from the eventual accumulation of acidic toxins.

Glutathione is not yet a household word. Even some medical and holistic doctors who have heard the term may still have only a vague idea of what it is. However, everyone will soon be talking about this critical non-nutritive substance.

There was a time when only scientists had heard of cholesterol and vitamins, but today, everyone knows about them. Now the magnificence of glutathione is becoming known.

In the last five years, over 25,000 medical articles about this substance have been published, and the scientific understanding of glutathione is gradually becoming common knowledge.

Each and every cell in the body is responsible for its own supply of glutathione and must have the necessary raw materials in order to produce it. Glutathione is always in great demand and is rapidly consumed when we experience any sort of emotional or physical stress, fatigue and even moderate exercise.

Some well-known causes of glutathione depletion are as follows:

1) Acidic lifestyle and diet
2) Air and Water pollution
3) Prescription and recreational drugs
4) Ultraviolet and Radiation from cells phones, computers, electrical cars,
power lines, hair dryers, etc.
5) Emotional and physical stress
6) Injury, trauma or burns
7) Heavy metals
8) Cigarette smoke
9) Household chemicals
10) Acetaminophen poisoning
11) Exhaust from motor vehicles
12) Septic shock
All of these above factors lead to a build up of acidic toxins that cause
the loss of glutathione as a non-nutritive buffer leading to cellular aging,
disease and finally death.

Why is Glutathione Essential to Health?

Glutathione's three major roles in the body are summarized by the letters
A-B-C.

- Anti-oxidant
- Blood Booster
- Cell Detoxifier

These are the three critical processes driven by glutathione.

The Master Antioxidant

Over the past thirty years, researchers have explored the role of antioxidants in good health as well as the treatment and prevention of diseases involving oxidation or fermentation by metabolic acids.

Well known and widely used antioxidants such as vitamin A, vitamin E and selenium neutralize acid. They occur naturally in nature, but not in the body. They must be introduced as part of a balanced diet.

Given the critical role of antioxidants in good health, it is not surprising that the body itself manufactures its own natural antioxidants. The most important of these is glutathione. Because all other antioxidants
depend upon the presence of glutathione to function properly, scientists call it 'the master antioxidant.'

Glutathione binds to toxins, forming a water-soluble complex - which is ultimately excreted in the urine or bile as waste.

Food for the Blood

Elevated glutathione levels enable the body to produce more white blood cells. White blood cells are the body's garbage collectors and are the most important cells for maintaining sterility of the body fluids.

Glutathione plays a central role in the proper function of the white blood cells. Dr. Gustavo Bounous, a leading glutathione expert, says, 'The limiting factor in the proper activity of our lymphocytes (the white blood cells) is the availability of glutathione.' In other words, healthy growth and activity of the white blood cells depends upon glutathione's availability. Put simply, glutathione is 'food' for the white blood cells.

Cellular Detoxifier

Whether we know it or not, we are continually inhaling and ingesting natural and synthetic acidic toxins. They are unavoidable in these modern times both in our polluted cities and our poorly engineered food supplies. When the body has the health and the nourishment it needs, it works tirelessly to eliminate acidic toxins and to protect itself. But, increasing levels of environmental pollution are depleting the body's store of glutathione more and more rapidly. Our main organ of detoxification of acidic waste products is the lymphatic system and the liver. This is the body's most concentrated source of glutathione.

Studies show that low glutathione levels lead to poor lymphatic and liver function, causing more and more acidic toxins to circulate through the body and resulting in damage to individual cells and organs.

Medical doctors today routinely use glutathione- promoting drugs to detoxify victims of certain types of drug overdose.

Glutathione in Natural Medicine

Practitioners of complementary and alternative medicine (CAM) have long advocated the use of milk thistle for liver problems. It turns out that this herb works by modestly elevating glutathione levels. The mineral selenium also produces subtle elevations in glutathione by becoming integrated into the glutathione peroxidase.

Glutathione in Traditional Medicine

Emergency medical doctors, toxicologists and lung and liver specialists are well acquainted with glutathione's therapeutic uses. American physicians seeking ways to raise a patient's glutathione levels can open the standard Physician's Desk Reference (PDR) and find two options - the pharmaceutical drugs sold under the names Parlodex and Mucomyst, and the natural dietary supplement found in natural foods stores derived from whey protein isolate.

Drugs That Raise Glutathione Levels

Pharmaceutical drugs like Procysteine, OTC, OTX, Glutathione monoesters and Glutathione diesters have been used to raise glutathione levels. However, they all produce side effects and are unsuitable for long term use.

This pharmaceutical non-nutritive chemical is used to break up mucus in lung diseases such as cystic fibrosis, chronic bronchitis and asthma. It remains the standard treatment for acetaminophen overdose.

Glutathione in Health and Disease

It is believed that glutathione has an important role to play in the prevention and treatment of disease. It may in the future be considered as important to health as an alkaline diet, exercise and alkaline lifestyle. Clinical tests show that raised glutathione levels may address some of the eight major health issues of our time:

1) Cardiovascular

- Prevents heart disease - Shimizu H, Kiyohara Y, Kitazono T, Kubo M, Ibayashi S, Fufishima M, Lida M. Relationship Between Plasma Glutathione Levels and Cardiovascular Disease in a Defined Population: The Hisyama Study. Stroke. 2004 Sep; 35(9):2072-7.
- Prevents stroke - Paterson PG, Juurlink BH. Nutritional Regulation of Glutathione in Stroke. Neurtox Res. 1999 Dec; 1(2): 99-112.
- Prevents atherosclerosis - Coppola L, Grassia A, Giunta R. Glutathione Improves Hemostatic and Hemorrheological Parameters in Atherosclerotic Subject. Drugs Exp. Clin Res 1992 18:493-98

- Reverses atherosclerosis
- Prevents reperfusion injury

2) Cancer

Cancer causing polychlorinated biphenyls (PCBs) have been found to alter levels of glutathione compounds in experiments, which may alter the body's resistance to certain types of cancer.

Glutathione deficiencies have been linked to many forms of cancer.

- Prevents cancerous tissue
- Suppresses tumor growth
- Eliminates carcinogen - acids
- Retards oxidative stress
- Prevents wasting disease
- Eases side effects of chemotherapy and radiotherapy

3) Pulmonary

Glutathione is the most efficient free radical (acid) scavenger in the airways, and dozens of studies have confirmed that free radical (acid) damage is a primary player in Chronic Obstructive Pulmonary Disease. Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. 2000 Sep; 16(3):534-54.

- Breaks up mucus - Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. 2000 Sep; 16(3):534-54

- Cystic fibrosis - Glutathione neutralized harmful oxidants introduced into the lungs or those released by cells. Exotoxins from bacteria can overload the endobronchial terrain and feed the fires of acidic inflammation. This staggering burden increases the oxidative sensitivity of the CF lung, resulting in further injury of lung parenchyma. Data supports evidence of a decrease in the antioxidant tri-peptide glutathione (Roum JH, Buhl R, McElvaney NG, et al. Systemic Deficiency of Glutathione in Systic Fibrosis. J Appl Physiol 1993; 75:19-24).

- Asthma
- Chronic bronchitis

- Emphysema - Lamson, David, MD, Grignall, Matthew, ND. The use of Nebulized Glutathione in the Treatment of Emphysema: A Case Report. Altern Med Review. 5(5);429-431, 2000 Oct.

- Pulmonary fibrosis - Ishii T, Fujishiro M, Nakajima J, Teramoto S, Ouchi Y, Matsuse T. Depletion of Glutathion S-Transferase P1 Induces Apoptosis in Human Lung Fibroblasts. Exp Lung Res. 29(7);523-36, 2003 Oct-Nov.

4) Aging

Glutathione is critically important to our brain as it is one of the most important brain antioxidants. Glutathione helps preserve brain tissue by preventing damage from free radicals (acids).

In addition to quenching dangerous acids, glutathione also acts to recycle vitamin E which also has the ability to reduce acidity in the brain. (Perlmutter D., BrainRecovery.com July 2004, 5th ed:13)

- Autism - Medical literature documents that an out-fection can lead to a lowering of glutathione which participates in detoxification, interacts with metallothioneins, and supports many crucial aspects of immunity. A link between glutathione and autism regression may derive from the fact that transient or chronic intestinal problems can impair an infant's or toddler's nutritional status, thereby minimizing the levels of amino-acids required for the production of glutathione (McCandless, J. Children With Starving Brains. 2003, 2nd ed; 252)

- Parkinson's Disease - Glutathione helps to preserve brain tissue by preventing damage from free radicals (acids) and destructive chemicals formed by the normal processes of metabolism, toxic elements in the environment, and as a normal response of the body to challenges by acidic agents or other stresses. With the understanding that glutathione is important for brain protection and that this protection many be lacking in the brains of Parkinson's clients due to glutathione deficiency, it can be seen as very beneficial. (Di Monte DA, Cahn P, Sandy MS. Glutathione in Parkinson's Disease: A Link Between Oxidative Stress and Mitochondrial Damage? An Neurol. 32 Suppl; S111-115, 1992.)

- Alzheimer's Disease - Woltjer, R.L., Hgheim W., Maezawa I., Vaisar T, Montine K.S., Montine T.J., Role of Glutathione in Intracellular Amyloid-Alpha Recursor Protein/Carboxy- Terminal Fragment Aggregation and Associated Cytotoxicity. J Neurochem. 2005 May; 93 (4): 1047-56.

- Huntington's Disease - Choo Y.S., Mao Z, Johnson GV, Lesort M. Increased Glutathione Levels In Cortical Striatal Mitochondria of the R6/2 Huntington's Disease Mouse Model. Neuroscience Letter. 2005 Sep 23; 386(1): 63-8.

- Multiple Sclerosis - Calabrese V, Scapaginini G, Ravagna A, Bella R, Butterfield DA, Calvani M, Pennisi G, Giuffrida Stella AM. Disruption of Thiol Homeostasis and Nitrostative Stress in the Cerebrospinal Fluid of Patients with Active Multiple Sclerosis: Evidence for a Protective Role of Acetylcarnitine. 2003 Sep; 28(9): 1321-8. Mann CL, Davies MB, Aldersea J, Fryer AA, Jones PK, Ko Ko C, Young C, Strange RC, Hawkins CP. Glutathione S-Transferase Polymorphisms in MS: Their Relationship to Disability. Neurology. 2000 Feb 8;54(3):542-7.

- ALS - Tohgi H, Abe T, Yamazaki K, Murata T, Ishizake E, Isobe C. Increase in Oxidized Products and Reduction in Oxidized Glutathione in Cerborospinal Fluid From Patients with Sporadic Form of Amyotrophic Lateral Sclerosis. Neurosci Lett. 1999 Feb 5; 260(3):204-6.

- Cataract formation
- Macular degeneration
- Cancers of aging
- Prostate problems

- Osteoarthritis - Hammarqvist F, Luo JL, cotgreave IA, Andersson K, Wernerman J. Skeletal Muscle Glutathione is Depleted In Critically Ill Patients. Crit Care Med. 25(1):78-84 1997 Jan.

5) Digestive

- Inflammatory bowel dis-ease
- Hepatitis
- Malnutrition
- Pancreatitis
- Peptic ulcer

6) Toxicology

- Detoxifies certain drug overdoses - Acetaminophen has been shown to reduce glutathione production, thus paving the way for enhanced brain destruction by metabolic acids. (Perlmutter D. July 2004, 5th ed:108)

- Detoxifies substances in cigarette smoke and auto exhaust - Rahman I, MacNee W. Lung Glutathione and Oxidative Stress: Implications In Cigarette Smoke-Induced Airway Disease. Am J Physiol. 277(6 Pt 1);1067-88, 1999 Dec.

- Detoxifies pollutants including heavy metals and pesticides - Elevated glutathione levels have been shown to protect tissue form lipid peroxidation created by exposure to certain metals. Consider infusions of glutathione to relieve the body burden of both neurotoxins and metal toxicity, including mercury. (Foster, JS. Kane PC, Speight N. The Detoxx Book. 2002;90)

- Prevents hearing loss from noise pollution
- Detoxifies many well-known carcinogens

7) Immunology

- Anti-viral for AIDS, hepatitis, herpes, etc. - Low glutathione levels in HIV clients may contribute to their immune deficiency since glutathione plays an important role in the function of lymphocytes. Some lymphocytes require adequate levels of glutathione in order to function normally, and HIV induces oxidative stress that depletes the cells of glutathione. Townsend DM, Tew KD, Tapero H. The Importance of Glutathione in Human Disease. Biomed Pharmacother. 2003 May-June;57(3-4):145-55. Droge W, Holm E. Role of Cysteine and Glutathione in HIV Infection and other Diseases Associated with Muscle Wasting and Immunological Dysfunction. FASEB J, 11(13):1077-89 1997 Nov.

- Lyme Disease - Lyme dis-ease is a seriously complex multi-system acidic inflammatory condition that is triggered by bacterial exotoxins. Glutathione helps to remove exotoxic and/or mycotoxic acids by forming a soluble compound with them, which can then be excreted through the urine or gut. (Can Glutathione Help Lyme Disease Suffers? Excerpt from: The Glutathione Report: Opitmal Health with the Master Antioxidant, Issue 4, Volume 1, May
2004).

- Natural antibiotic

- Chronic fatigue syndrome - An article in the journal of Medical Hypothesis proposed that glutathione, an antioxidant essential for lymphocyte function, may be depleted in Chronic Fatigue Syndrome patients. Glutathione is needed for both the immune system and for aerobic muscular contraction. The authors proposed that glutathione depletion by an activated immune system also causes the muscular fatigue and myalgia associated with Chronic Fatigue Syndrome (Bounous et al. 1999).

8) Metabolic

- Athletic enhancement
- Decreases recovery time from physical stress
- Supports hemoglobin in kidney failure

- Diabetes - The blood and tissues of diabetics are marked by critically
low glutathione levels. Glutathione depletion may have adverse consequences in diabetic clients independent of glycemic control, and it may weaken the defense against oxidative stress. De Mattia G, Bravi MC, Laurenti O, Cassone-Faldetta M, Armiento A, Ferri C, Falsano F. Influence of Reduced Glutathione Infusion on Glucose Metabolism in Patients with Non-insulin Dependent Diabetes Mellitus. Metabolism. 1998 Aug;47(8):433-8.

Glutathione provides the body with tools to fight off these threats naturally. Healthy people also benefit from elevated glutathione levels through an enhanced ability to fight off acidic toxins, dis-ease, pre-cancerous cells and the aging process itself. Diminished glutathione levels are a symptom of aging and are particularly evident in such aliments as Parkinson's dis-ease and Alzheimer's disease.

Glutathione is also important to physically active people. Many world-class athletes are discovering that well-maintained glutathione levels gives them the edge over their competitors, bringing greater strength and endurance, decreased recovery time from injury, less muscle pain and fatigue, and muscle-promoting activity.

Putting It All Together

1) Medical science is still ascertaining all the critical roles played by glutathione in dis-ease resistance and general good health. Clinical evidence links low glutathione levels to the most common illnesses of our time as well as newly emerging diseases.

2) As an essential aid to health, glutathione works as the master antioxidant in our body, optimizes the white blood cells and detoxifies a long list of pollutants and carcinogens or acids. The best way to raise glutathione levels is by eating foods that are high in glutathione such as avocados.

3) Pharmaceutical medicine has created drugs that do this very effectively. They have their uses in critical situations. But they also have side effects and repeated use is clearly inadvisable.

References:

Aging

It is well known that aging is accompanied by a precipitous fall in glutathione levels. Lower glutathione levels are implicated in many diseases associated with aging including cataracts, Alzheimer's, Parkinson's atherosclerosis and others. Journal of Clinical Epidemiology 47:1021-26, 1994.

Antioxidant Functions

Antioxidants are well documented and known to play vital roles in health maintenance and dis-ease prevention. Glutathione is your cell's own major antioxidant. Maintaining elevated glutathione levels aids the body's natural antioxidant function. Biochemical Pahrmacology 47: 2114-2123, 1994.

Neurological Disease

Low glutathione levels have been associated with neuro-degenerative diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig's Disease), Alzheimer's and Parkinson's. The Lancet 344: 796-798, 1994.

Cancer

Glutathione plays a role in eliminating many carcinogens/acids and also maintains and optimizes white blood cell function while providing stronger anti-acidic/anti-tumor defenses. Cancer Letters 57: 91-94, 1991.

Athletic Performance

Raised glutathione levels help increase strength and endurance. Those interested in physical fitness can benefit from a definite athletic edge. Journal of Applied Physiology 87: 1381-1385, 1999.

Toxins, Pollution and Radiation

Glutathione detoxifies a variety of pollutants, carcinogens and poisons including many found in fuel exhaust and cigarette smoke. It also retards damage from radiation exposure due to the eroding ozone layer. Annual Reviews of Biochemistry 52: 711-760, 1983

AIDS

Glutathione levels correspond to poor survival of AIDS patients. Much documentation demonstrates the role of enhanced glutathione levels in AIDS. Proceedings of the National Academy of Science, USA 94: 1967-72, 1997.

Heart Disease, Stroke and Cholesterol

Raised glutathione levels fight the oxidation of fats circulating in the bloodstream including cholesterol, retarding the process of plaque formation in the arteries leading to most heart attacks and strokes. Nutrition Reviews 54: 1-30, 1996.

Diabetes

Diabetics are more prone to 'out-fections' and circulatory problems leading to heart dis-ease, kidney failure and blindness. Glutathione protects against the complications of diabetes. Clinical Science 91:575-582, 1996

Lung Disease

Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. New and potentially therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses.

American Journal of Medical Science 307:119-127, 1994

Digestive Disorders

Glutathione protects the body from inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn's dis-ease. Gut 42: 485-492, 1998

Hepatitis

The liver is a major storehouse for glutathione.
Glutathione is impaired in alcohol hepatitis as well as in viral (acidic) hepatitis including hepatitis A, B, and C. Raised glutathione levels help restore liver function. American Journal of Gastroenterology 91: 2569-2573, 1996 Kidney Disease

Those with kidney failure or on dialysis suffer from high levels of oxidative (acidic) stress and decreased glutathione levels. Raised glutathione levels help prevent anemia. Nephron 61: 404-408, 1992

Pregnancy, Lactation and Childbirth

Glutathione's role in fetal and placental development is critical. It also acts in the placenta to detoxify pollutants before they can reach the developing child. Many complications of pregnancy have been linked with poor glutathione levels.

Early Human Development 37: 167-174, 1994

Did you know glutathione (GSH) is the most powerful, prevalent antioxidant in your body? Increasing your glutathione level will naturally increase your energy, detoxify your body and strengthen your immune system.

Glutathione: The Body's Master Antioxidant glutathione (GSH) is a small protein produced naturally in our cells when certain required elements are present. It functions both as an antioxidant and an antitoxin and is a major defense system against illness and aging. Our glutathione level actually indicates our state of health and can predict longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine. In the near future the importance of glutathione will be widely recognized because it has the ability to boost the immune system and fight off the damage of free radicals on the cells.

Glutathione has been shown to slow down the aging process, detoxify and improve liver function, strengthen the immune system, and reduce the chances of developing cancer.

Glutathione also works to help improve mental functions, increase energy, improve concentration, permit increased exercise, and improve heart and lung function - just to name a few.

Increasing Age and Other Factors Reduce the Body's Production and Utilization of GSH. Research has shown that individuals who have low levels of glutathione are susceptible to chronic illness. Research shows that GSH levels decline by 8% to 12% per decade, beginning at the age of 20. Levels of glutathione are further reduced by continual stress upon the immune system such as illness, infection, and environmental toxins. As we now know, a lowered immune system can bring about illness and disease. This is a ferocious cycle. While you need glutathione for a productive immune system, a weakened immune system hampers the production of glutathione. The consequences of sustained GSH depletion are fatal. As cellular GSH is depleted, first individual cells die in those areas most affected. Then zones of tissue damage begin to appear. Localized free-radical damage spreads across the tissue in an ever-widening, self-propagating wave

MaxGXL™ Patented Formula Dramatically Increases Intercellular GSH

MaxGXL™ provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione.

MaxGXL™ also aids in liver support. by destroying environmental toxins, thus helping the liver to function as the main production site and storehouse for glutathione.

MaxGXL™ effectiveness not only in populations who are immune-suppressed, but also in those who are stressed, aging, lacking sleep, or with any prolonged illness. Such as chronic viral infections: HIV infections, hepatitis C, chronic fatigue, immuno deficiency syndrome, immune deficiencies, cancer, B-cell malignancies, including lymphomas, chronic leukemia, myeloma, Waldenstrom's, MGUS, pulmonary oxygen toxicity, adult respiratory distress syndrome, broncopulmonery dysplasia, sepis syndrome, Parkinson's disease, encephalitis, endotoxemia, anoxia induced neuronal damage, ischemic reperfusion injury, inflammatory diseases, systemic lupus erythematosis, myocardial infarction, stroke, traumatic hemorrhage, spinal cord trauma, Crohn's disease, rheumatoid arthritis, diabetes, cataract formation, uvetis, emphysema, gastric ulcers, oxygen toxicity, neoplasia, undesired cell apoptosis, radiation sickness, including hepatic dysfunction, malignancies, pulmonary disease, related immunologic illnesses and physiological conditions. e.t.c. improves immune defense productions and thereby mitigate the progression of the illnesses to thereby limit fatigue, decreases the biologic effects of stress, increases energy and improves physical performance, In these situations, MaxGXL™ stimulates the body's production of glutathione to compensate for the body's accelerated use of it, strengthening your natural defenses, decreasing your risk of illness, and guarding against the effects of the body's aging process.

Supplements Containing Glutathione Alone Will NOT Increase The Body's GSH Levels. It is pointless to purchase supplements that merely contain glutathione, because the digestive system breaks down ingested glutathione and it will not be absorbed into your system. On the other hand, MaxGXL™ provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione. MaxGXL™ also aids in liver support by destroying environmental poisons helping the liver to function as the main production site and storehouse for glutathione.

MaxGXL™ improves your health and well-being by helping your body increased its natural Glutathione levels. As we age, our body's production of Glutathione declines to a trickle. Every cell in your body needs Glutathione to function.

"Glutathione naturally protects you from the long-term dangers of.... cancer, heart disease, diabetes, premature aging, autoimmune disease, inflamation, and chronic illnesses such as asthma. Keeping your Glutathione level high helps you stay healthy and active." Alan Pressman, DC, Phd, CCN

Glutathione is your best defender against illnesses, infections, inflamation, toxins, and diseases. GSH is critical to optimum brain function, and it is your body's first line of defense against diseases of aging, the harmful affects of stress and overexertion, illness, infection, toxins and free radical damage.

The systemic administration of MaxGXL™ to mammals suffering from hepatitis, stimulates the natural production of glutathione in the biologically active cells of the mammal.

The systemic administration of MaxGXL™ in mammals suffering from allergies, stimulates the natural production of glutathione in the biologically active cells of the mammal and to promote the shift of the T-cell balance from TH2 to TH1 and decrease levels of IgE.

The systemic administration of MaxGXL™ decreases serum cholesterol and triglycerides.

MaxGXL™ includes a probiotic, said probiotic promotes the breakdown and absorption of nutrients, the elimination of toxins and to inhibit the growth of harmful bacteria in the gastrointestinal tract, thereby facilitating the absorption of N-acetylcysteine into the gastrointestinal tract. The probiotic is a composition of "healthy bacteria" containing one or more of said healthy bacteria selected from the group comprising bifidobacterium longum, bifidobacterium infantis, lactobacillus acidophilus, lactobacillus casei, lactobacillus rhamnosus, saccharomyces boulardi, propionibacteria and enterococci.

Important Notice: These statements have not been evaluated by the Food and Drug Administration. These products are not intended for use in the treatment of any disease.

MaxGXL™ Supplement Facts.......Serving Size 3 Capsules.......56 Servings Per Box.......Vitamin C (as Calcium Ascorbate) 250 mg.......N Acetyl Cysteine 375 mg.......L-glutamine 750 mg.......N Acetyl D-Glucosamine 125 mg.......Quercetin 37.5 mg.......Milk Thistle Extract 25 mg.......Alpha Lipoic Acid 75 mg.......Cordyceps 300 mg.......Conjugated Linoleic Acid 100 mg.......Other Ingredients: Gelatin Capsules........

Cost of MaxGXL™ is 75.95 for a 4 week supply on autoship........ Please call (702)-334-1426 and leave your name and number and best time for me to return your call to start your monthly autoship of MaxGXL's™......... If you prefer you may email studiorich@aol.com Please leave your name, address, city, state, zipcode, email, telephone number, charge card number and expiration. And you will be billed 75.95 each month, and you will recieve a 4 week supply every month, that will be mailed to you. Shipping cost is included in the 75.95 price........ Write me the above information, and mail to: Richard Adkins 10512 Snyder Ave. Las Vegas, NV 89134 or click this link to learn more, or to order: http://www.maxgxl.com/radkins

Did you know glutathione is the most powerful, prevalent antioxidant in your body? Increasing your glutathione level will naturally increase your energy, detoxify your body and strengthen your immune system. Systemic administration of MaxGXL™ decreases fatigue in patients suffering from a variety of illnesses including but not limited to chronic viral infections, HIV, hepatitis C, chronic fatigue, immuno deficiency syndrome, immune deficiencies, cancer, B-cell malignancies, including lymphomas, chronic leukemia, myeloma Waldenstrom's and MGUS. This makes the composition function as both a pharmaceutical and a therapeutic substance for patients suffering from the debilitating conditions.

MaxGXL’s™ Patented Formula Dramatically Increases Intercellular GSH..

MaxGXL™ provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione. MaxGXL™ also aids in liver support. by destroying environmental toxins, thus helping the liver to function as the main production site and storehouse for glutathione.

MaxGXL‘s™ effectiveness not only in populations who are immune-suppressed, but also in those who are stressed, aging, lacking sleep, or with any prolonged illness. In these situations, MaxGXL™ stimulates the body's production of glutathione to compensate for the body's accelerated use of it, strengthening your natural defenses, decreasing your risk of illness, and guarding against the effects of the body's aging process.

Glutathione: The Body's Master Antioxidant glutathione (GSH) is a small protein produced naturally in our cells when certain required elements are present. It functions both as an antioxidant and an antitoxin and is a major defense system against illness and aging. Our glutathione level actually indicates our state of health and can predict longevity. Although there are more than 60,000 published papers on the beneficial effects of glutathione replacement, it is still largely ignored by mainstream medicine. . In the near future the importance of glutathione will be widely recognized because it has the ability to boost the immune system and fight off the damage of free radicals on the cells.

Glutathione has been shown to slow down the aging process, detoxify and improve liver function, strengthen the immune system, and reduce the chances of developing cancer. Glutathione also works to help improve mental functions, increase energy, improve concentration, permit increased exercise, and improve heart and lung function - just to name a few.

Increasing Age and Other Factors Reduce the Body’s Production and Utilization of GSH. Research has shown that individuals who have low levels of glutathione are susceptible to chronic illness. Research shows that GSH levels decline by 8% to 12% per decade, beginning at the age of 20. Levels of glutathione are further reduced by continual stress upon the immune system such as illness, infection, and environmental toxins. As we now know, a lowered immune system can bring about illness and disease. This is a ferocious cycle. While you need glutathione for a productive immune system, a weakened immune system hampers the production of glutathione.

Supplements Containing Glutathione Alone Will NOT Increase The Body’s GSH Levels. It is pointless to purchase supplements that merely contain glutathione, because the digestive system breaks down ingested glutathione and it will not be absorbed into your system. On the other hand, MaxGXL™ provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione. MaxGXL™ also aids in liver support by destroying environmental poisons helping the liver to function as the main production site and storehouse for glutathione.

See Interview with Dr. Keller on MaxGXL Call Richard for free information pack @ 702-341-7664

MAXGXL, has been awarded a U.S. Composition Patent, SHOWN BELOW ... because it is so unique in how it increases the body's production of Glutathione-a major component of every living cell in your body.

The phenomenal MAXGXL compound ..... increases the normal GSH levels in your body ..... Restores Glutathione levels in your body, to where it should be ..... increase your energy level ..... detoxify your body ..... strengthen your immune system ..... enhance your athletic performance ..... and helps reduce inflamation in every cell of your body.

The worlds most powerful Antioxidant is not a Berry, a Fruit or a Drink. It is in your Body-Glutathione (GSH). Every cell in your body requires an adequate supply of Glutathione to function and to stay healthy.

MAXGXL improves your health and well-being by helping your body increased its natural Glutathione levels. As we age, our body's production of Glutathione declines to a trickle. Every cell in your body needs Glutathione to function.

"Glutathione naturally protects you from the long-term dangers of.... cancer, heart disease, diabetes, premature aging, autoimmune disease, inflamation, and chronic illnesses such as asthma. Keeping your Glutathione level high helps you stay healthy and active." Alan Pressman, DC, Phd, CCN

Glutathione is your best defender against illnesses, infections, inflamation, toxins, and diseases. GSH is critical to optimum brain function, and it is your body's first line of defense against diseases of aging, the harmful affects of stress and overexertion, illness, infection, toxins and free radical damage.

When we are in our 20s our bodies produce normal levels of Glutathione, but as we age and approach our forties and beyond our body's production of this powerful disease fighting compound slows to a trickle. Without adequate GSH our bodies develop diseases and makes us prone to a multitude of illnesses and disorders. It is amazing how fast Max GXL can restore Glutathione levels in your body to give you increased levels of energy, protection from diseases, toxins, and stress related illnesses, and helps to reduce inflamation in every cell of your body.

Copy these links into your browser, and listen to the calls on Dr. Tai, Steve Scott, and Dr. Nelson

Dr. Tai http://www.byoaudio.com/play/WsqZRDNx

Dr. Nelson http://www.byoaudio.com/play/W1P39Psx

Steve Scott http://www.byoaudio.com/play/W1TJsXtx

Cost of MaxGXL™ is 75.95 for a 4 week supply on autoship........ Please call (702)-334-1426 and leave your name and number and best time for me to return your call to start your monthly autoship of MaxGXL's™......... If you prefer you may email studiorich@aol.com Please leave your name, address, city, state, zipcode, email, telephone number, charge card number and expiration. And you will be billed 75.95 each month, and you will recieve a 4 week supply every month, that will be mailed to you. Shipping cost is included in the 75.95 price.........Write me the above information, and mail to: Richard Adkins 10512 Snyder Ave. Las Vegas, NV 89134 or click this link to learn more, or to order: http://www.maxgxl.com/radkins

Robert Keller MD, MS, FACP, has been named as one of the world’s 2,000 Outstanding Scientists of the 21st Century, and has served on the scientific review panels for the National Institutes of Health and the VA.

Dr. Keller has served on the faculties of the Mayo Graduate School of Medicine, the University of Wisconsin and the Medical College of Wisconsin (Marquette Univ.) He has published more than 100 original articles in various scientific and medical journals and has been awarded several patents. Dr Keller was elected to The Board of Governors of the American Academy of HIV medicine, and serves on the Scientific Advisory Board of several Biotech companies. The Consumers’ Research Council has named Dr. Keller one of America’s “Top Physicians in 2003, 2004 and 2005 in the fields of Internal Medicine, Immunology and Hematology. Dr. Keller continues his medical practice and research activities at his clinic and laboratory in Florida and is Chairman of the Board and Chief Scientific Officer of Phoenix Biosciences, Inc.

United States Patent 6,262,019
Keller , et al. July 17, 2001

Method of treatment of glutathione deficient mammals
Abstract
Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intracellulary either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate), by way of inhibition of synthesis, or by subjecting cells to oxidant stress. Most cells, except for epithelia cells, do not have a direct transport capacity for intact GSH. Non-epithelial cells must either transport precursor substrates for GSH synthesis or salvage amino acids from circulating GSH for reuse in intracellular resynthesis. Dietary cysteine is a rate limiting substrate for the synthesis of glutathione and also inhibits GSH efflux. Although GSH is synthesized from precursors in virtually all cells, the liver is the main source of plasma GSH. Protection and support of liver function is paramount to elevating GSH levels. The disclosure is also of a unique combination of nutritional supplements including n-acetyl cysteine, vitamin C, l-glucosamine, n-acetyl d-glucosamine, quercitin, sylimarin, Alpha lipoic acid and high protein, low fat whey that are combined to support various bodily systems involved in glutathione synthesis, reutilization and storage; all intended to elevate glutathione concentration in the mammalian cell.

Inventors: Keller; Robert H (Weston, FL), Kirshenbaum; David W (Weston, FL)
Assignee: Vit-Immune, L. C. (Hollywood, FL)
Appl. No.: 09/302,217
Filed: April 29, 1999

Current U.S. Class: 514/2 ; 424/49; 424/535; 424/54; 424/655; 514/12; 514/21; 514/23; 514/251; 514/276; 514/7; 530/365; 530/833
Current International Class: A23L 1/302 (20060101); A23L 1/305 (20060101); A23L 1/30 (20060101); A61K 31/185 (20060101); A61K 31/197 (20060101); A61K 31/70 (20060101); A61K 31/375 (20060101); A01N 037/18 (); A61K 038/02 ()
Field of Search: 514/2,7,12,23,21,251,276 424/54,49,535,655 530/365,833

References Cited [Referenced By]

U.S. Patent Documents

4256760 March 1981 Los
4277496 July 1981 Los
4292403 September 1981 Duermeyer
5290571 March 1994 Bounous et al.
5456924 October 1995 Bounous et al.
5696109 December 1997 Malfroy-Camine et al.

Other ReferencesPROMT on STN, Information Access Company, 1998: 1310, BioDynamax Supplement--Ultra Antioxidants Tablets, Product Alert (Dec. 22, 1997) ISSN: 0740-3801.* ."Screening of Potential Chemopreventive Agents Using Biochemical Markets of Carcinogenesis" by Sheela Sharma, Jill D. Stutzman, Gary J. Kelloff and Vernon E. Steele, Cancer Resreach 54, 5848-5855, Nov. 15, 1994. .Low Blood Glutathione Levels in Healthy Aging Adults, pp 720-725, Calvin A. Long, et al. .a-Lipoic Acid: Biological Effects and Clinical Implications, pp 177-183, Trent W. Nichols, Jr. M.D. .Glutathione: Systemic Protectant Against Oxidative and Free Radical Damage, pp 155-171, 173-176, Parris M. Kidd, Ph.D. .Importance And Regulation of Hepatic Glutathione, pp 251-266, Laurie D. Deleve, M.D., Ph.D. et al. .Probiotics in Human Medicine, pp 439-442, R. Fuller. .Aids Wasting Syndrome as an Entero--Metabolic Disorder: The Gut Hypothesis, pp 40-45, 47-43, Mitchell Kaminski, Jr., M.D., et al. .The Effects of L-Glutamine, N-Acetyl-D-Glucosamine, Gamma-Linolenic Acid and Gamma-Oryzanol on Intestinal Permeability..

Primary Examiner: Carlson; Karen Cochrane
Assistant Examiner: Tu; Stephen
Attorney, Agent or Firm: Pitney, Hardin, Kipp & Szuch, LLP

Parent Case Text

This application claims the benefit of Provisional No. 60/083,661 filed Apr. 30, 1998.

Claims

What is claimed is:

1. A composition of matter, which comprises in admixture;

N-acetylcysteine; N-acetyl-d-glucosamine vitamin C whereby the amount of vitamin C is in an amount of at least 1000 mg. or greater to facilitate the absorption of N-acetylcysteine across the cellular membrane; and,

a pharmaceutically acceptable carrier for oral administration.

2. The composition of claim 1 further comprising one or more of the following substances from the group consisting of alpha-lipoic acid, sylmarin, quercitin, l-glutamine, a probiotic, and dietary protein.

3. The composition of claim 1 further comprising alpha-lipoic acid, sylmarin, quercitin, l-glutamine, and a probiotic.

4. The composition of claim 3 further comprising dietary protein.

5. The composition of claim 1 further comprising flavorants.

6. The systematic administration of a pharmaceutically effective amount of the composition according to claim 1 to a mammal suffering from low glutathione levels, to stimulate the natural production of glutathione in the biologically active cells of the mammal.

7. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal suffering from hepatitis, to stimulate the natural production of glutathione in the biologically active cells of the mammal.

8. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal suffering from HIV, to stimulate the natural production of glutathione in the biologically active cells of the mammal.

9. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal suffering from allergies, to stimulate the natural production of glutathione in the biologically active cells of the mammal and to promote the shift of the T-cell balance from TH2 to TH1 and decrease levels of IgE.

10. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal to decrease serum cholesterol and triglycerides.

11. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal suffering from one or more of the following illnesses from the group consisting of chronic viral infections: HIV, hepatitis C, chronic fatigue, immuno deficiency syndrome, immune deficiencies, cancer, B-cell malignancies, including lymphomas, chronic leukemia, myeloma Waldenstrom's and MGUS to improve immune defense productions and thereby mitigate the progression of the illnesses to thereby limit fatigue.

12. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal to decrease fatigue.

13. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal to decrease the biologic effects of stress.

14. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal to increase energy and improve physical performance.

15. Administration according to claim 6 wherein a pharmaceutically effective amount is 0.1 mg/kg to about 50 mg/kg of body weight of the mammal, daily.

16. Administration according to claim 6 wherein a pharmaceutically effective amount is 0.5 mg/kg to about 25 mg/kg of body weight of the mammal, daily.

17. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal suffering from low glutathione levels, to stimulate the natural production of glutathione in the biologically active cells of the mammal.

18. The systemic administration of a pharmaceutically effective amount of the composition according to claim 3 to a mammal suffering from low glutathione levels, to stimulate the natural production of glutathione in the biologically active cells of the mammal.

19. The systemic administration of a pharmaceutically effective amount of the composition according to claim 1 to a mammal suffering from low glutathione levels, to stimulate the natural production of glutathione in the biologically active cells of the mammal and reduce symptoms of diseases caused by excess unneutralized free radicals.

20. The systemic administration of a pharmaceutically effective amount of the composition according to claim 2 to a mammal suffering from low glutathione levels, to stimulate the natural production of glutathione in the biologically active cells of the mammal and reduce symptoms of diseases caused by excess unneutralized free radicals.

21. The systemic administration of a pharmaceutically effective amount of the composition according to claim 3 to a mammal suffering from low glutathione levels, to stimulate the natural production of glutathione in the biologically active cells of the mammal and reduce symptoms of diseases caused by excess unneutralized free radicals.

22. The systemic administration of a pharmaceutically effective amount of the composition according to claim 19, wherein the disease is a member of the group consisting of pulmonary oxygen toxicity, adult respiratory distress syndrome, broncopulmonery dysplasia, sepis syndrome, Parkinson's disease, encephalitis, endotoxemia, anoxia induced neuronal damage, ischemic reperfusion injury, inflammatory diseases, systemic lupus erythematosis, myocardial infarction, stroke, traumatic hemorrhage, spinal cord trauma, Crohn's disease, rheumatoid arthritis, diabetes, cataract formation, uvetis, emphysema, gastric ulcers, oxygen toxicity, neoplasia, undesired cell apoptosis, radiation sickness.

23. The systemic administration of a pharmaceutically effective amount of the composition according to claim 20, wherein the disease is a member of the group consisting of pulmonary oxygen toxicity, adult respiratory distress syndrome, broncopulmonery dysplasia, sepis syndrome, Parkinson's disease, encephalitis, endotoxemia, anoxia induced neuronal damage, ischemic reperfusion injury, inflammatory diseases, systemic lupus erythematosis, myocardial infarction, stroke, traumatic hemorrhage, spinal cord trauma, Crohn's disease, rheumatoid arthritis, diabetes, cataract formation, uvetis, emphysema, gastric ulcers, oxygen toxicity, neoplasia, undesired cell apoptosis, radiation sickness.

24. The systemic administration of a pharmaceutically effective amount of the composition according to claim 21, wherein the disease is a member of the group consisting of pulmonary oxygen toxicity, adult respiratory distress syndrome, broncopulmonery dysplasia, sepis syndrome, Parkinson's disease, encephalitis, endotoxemia, anoxia induced neuronal damage, ischemic reperfusion injury, inflammatory diseases, systemic lupus erythematosis, myocardial infarction, stroke, traumatic hemorrhage, spinal cord trauma, Crohn's disease, rheumatoid arthritis, diabetes, cataract formation, uvetis, emphysema, gastric ulcers, oxygen toxicity, neoplasia, undesired cell apoptosis, radiation sickness.

25. The systemic administration of a pharmaceutically effective amount of the composition according to claim 1 to a mammal, to promote the natural production of glutathione in the biologically active cells of the mammal which accelerates the detoxification of ethanol and alleviates symptoms associated with excessive ethanol imbibation.

26. The composition of claim 1 further comprising a probiotic, said probiotic for promoting the breakdown and absorption of nutrients, the elimination of toxins and to inhibit the growth of harmful bacteria in the gastrointestinal tract, thereby facilitating the absorption of N-acetylcysteine into the gastrointestinal tract.

27. The probiotic of claim 1, wherein said probiotic is a composition of "healthy bacteria" containing one or more of said healthy bacteria selected from the group comprising bifidobacterium longum, bifidobacterium infantis, lactobacillus acidophilus, lactobacillus casei, lactobacillus rhamnosus, saccharomyces boulardi, propionibacteria and enterococci.

28. The composition of claim 2 further comprising 1-glutamine, said component being an essential dietary component to promote the support of gastrointestinal growth and function, thus facilitating the absorption of N-acetylcysteine through the gastrointestinal tract.

29. The composition of claim 4 wherein N-acetyl-d-glucosamine promotes the biosynthesis of mucosal glycoproteins which make up the glycocalyx, a layer of the gut mucosa which acts to protect the tissue of the gastrointestinal tract while providing a selectively absorptive surface, thus facilitating the absorption of N-acetylcysteine into the gastrointestinal tracts.

Description

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention provides a method of improving glutathione (GSH) concentrations, both intra and extra-cellularly, in mammals, thereby improving the cellular and humoral immune response. It comprises oral administration of a therapeutically effective amount of nutritional supplement which is composed of critical and synergistic quantities of amino acids, peptides, and bioflavanoids.

2. Brief Description of Related Art

Glutathione is a well-known tripeptide, which exists in two basic forms. The antioxidant form or "reduced glutathione" tripeptide is conventionally called "glutathione" and abbreviated as "GSH". The oxidized form is a sulfur-sulfur linked compound known as glutathione disulfide (GSSG).

Glutathione in its biologically active, reduced form (GSH) has the formula: ##STR1##

and is appropriately named .gamma.-L-Glutamyl-L-cysteinylglycine. It is ubiquitous in animals, plants, and microorganisms and being water soluble is found mainly in the cell cytosol and other aqueous phases of the living system. Glutathione often attains millimolar levels inside living cells, which makes it one of the most highly concentrated intracellular antioxidants.

Glutathione is homeostatically controlled, both inside the animal cell and outside. Enzyme systems synthesize it, utilize it, and regenerate it per the gamma-glutamyl cycle. (Meister A. Glutathione, Ascorbate and Cellular Protection Cancer Res (Suppl) 1994 (Apr 1); 54:1969S-1975S).

Glutathione is most concentrated in the mammal liver (10 mM), where the P450 Phase II" enzymes require it to convert fat-soluble substances into water-soluble GSH conjugates in order to facilitate their excretion. While providing GSH for their specific needs, the liver parenchymal cells export GSH to the outside, where it serves as systemic source of-SH/reducing power.

Briefly, glutathione synthesis occurs within animal cells in two closely linked enzymatically controlled reactions that utilize Adenosine Triphosphate (ATP) and draw on nonessential amino acids as substrates. First, cysteine and glutamate are combined (by the enzyme gamma-glutamyl cysteinyl synthetase, with availability of cysteine usually being the rate-limiting factor. Cysteine is generated from the essential amino acid methionine, from the degradation of dietary protein, or from turnover of endogenous proteins. The buildup of GSH acts to feedback-inhibit this enzyme, thereby helping to ensure homeostatic control over GSH synthesis.

The second GSH synthesis reaction combines gamma-glutamylcysteine with glycine to generate GSH (catalyzed by GSH synthetase).

With regard to the essentiality of GSH for the survival of the mammal, substantial information is available from studies on hereditary GSH depletion in the human, and from experimental depletion and repletion of GSH in animal models and cell cultures, see for example: Meister A. Larsson A. Glutathione Synthetase Deficiency and Other Disorders of the Gamma-Glutamyl Cycle; Scriver CR. et al eds. The Metabolic and Molecular Bases of Inherited Disease (Volume I). New York: McGraw-Hill: 1995:1461-1495 (Chapter 43); and Beutler E. Nutritional and Metabolic Aspects of Glutathione, Annu Rev Nutr 1989;9:287-302.

Reduced GSH levels in mammalian cells are associated with a wide variety of pathophysiologic states, including hepatic dysfunction, malignancies, HIV infection, pulmonary disease, Parkinson's disease, related immunologic illnesses and physiological conditions; see for example the descriptions in Kidd, Alternative Medicine Review, Vol. 2, No. 3, pages 156-176 (1997).

The consequences of sustained GSH depletion are fatal. As cellular GSH is depleted, first individual cells die in those areas most affected. Then zones of tissue damage begin to appear. Localized free-radical damage spreads across the tissue in an ever-widening, self-propagating wave.

An object of this invention is to promote gastrointestinal absorption and intracellular uptake of components which will maximize intracellular reduced glutathione production by a mammal including a human.

SUMMARY OF THE INVENTION

The invention comprises a composition of matter, which comprises in admixture:

N-acetylcysteine;

vitamin C; and

a pharmaceutically acceptable systemic carrier for oral administration.

In preferred embodiments, the invention further comprises one or more of the following:

alpha-lipoic acid;

sylmarin;

quercitin;

l-glutamine;

N-acetyl-d-glucosamine;

a probiotic.

The invention also comprises systemic administration of the composition of the invention to a mammal suffering from low glutathione levels, to stimulate the natural production of glutathione in the biological cells of the mammal.

The term "low glutathione levels" as used herein means a blood glutathione level below about 440 .mu.g glutathione/10.sup.10 erythrocytes, determined by the colorimetric method of Beutler et al., Improved Method for the Determination of Blood Glutathione, J. Lab. Clin. Med., 61;882-8(1963). Normal levels in humans ranges from about 440 to 654 .mu.g/10.sup.10 erythrocytes.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS OF THE INVENTION

Recently, there have been many scientific papers published discussing the direct relationship between decreased glutathione levels and the progression of many chronic diseases. Glutathione functions as an antioxidant, antitoxin and protector of red blood cells, and is extremely important to the immune system. It neutralizes free radicals minimizing the damage they cause and is profoundly important for cellular homeostasis.

As with other cell types, the proliferation, growth, and differentiation of immune cells is dependent on GSH. Both the T and the B lymphocytes require adequate levels of intracellular GSH to differentiate, and healthy humans with relatively low lymphocyte GSH were found to have significantly lower CD4 counts; Kinscherf R. Fischbach T. Mihm S. et al. Effect of glutathione depletion and oral N-acetylcysteine treatment on CD4+ and CD8+ cells. FASEB J 1994;8:448-451. Intracellular GSH is also required for the T-cell proliferative response to mitogenic stimulation, for the activation of cytotoxic T "killer" cells, and for many specific T-cell functions, including DNA synthesis for cell replication, as well as for the metabolism of interleukin-2 which is important for the mitogenic response; Wu D. Meydani S N, Sastre J. et al. In-vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects; J Nutr 1994;124:655-663.

In summary, it has been demonstrated that decreased levels of glutathione may be a result of various types of prolonged stress, increased free radical formation and hyperactivity of the immune system. These factors in turn compromise the health of mammalian cells. Despite the apparent importance of adequate glutathione levels, little emphasis has heretofore been placed on replacing depleted stores. Some glutathione comes from the diet but the majority is made in the liver.

Studies have demonstrated that oral glutathione supplementation is not well absorbed by many of the mammal's cells and does not replenish losses inside cells where it is most needed; Witschi A. Reddy S. Stofer B. et al. The systemic availability of Oral Glutathione. Eur. J Clin. Pharmacol. 1992;43:667-669.

The sulfur-containing amino acid l-cysteine is the precursor that most limits the cellular biosynthesis of GSH. When substituted into the diet in place of the total protein allowance it was effective in raising GSH levels (see Witschi et al., supra.)

Glutathione esters, synthetic compounds prepared by linking the glycol end of GSH into ester bonds, have been the subject of much research by Meister, Anderson, supra., as potential oral GSH delivery compounds (see also U.S. Pat. No. 4,784,685). These esters do appear to be effective GSH delivery vehicles, but have the disadvantage that they yield alcohols in vivo when their ester bonds are broken, and their safety over the long term has yet to be satisfactorily demonstrated.

We have discovered that to efficiently raise the level of glutathione intracellularly, it is necessary to employ several different mechanisms that work simultaneously. First, essential elements needed by the body for the manufacture of glutathione must be introduced. Second, gastro-intestinal health of the mammal must be optimal to facilitate nutrient absorption. Third, the liver function must be supported and protected as the liver is the glutathione "manufacturing and storage house". Lastly, recycling existing glutathione and enhancing enzymatic reactions that promote glutathione synthesis are also important functions which are advantageous to support.

The essential element needed by the mammalian cell to manufacture glutathione (GSH) is N-acetylcysteine (NAC). It has proven to be the most efficient dietary source of glutathione precursor. It is a precursor and the main limiting factor necessary for the body to manufacture reduced glutathione. NAC is well absorbed by the intestine and readily converted by the mammalian cell (particularly in the liver) to glutathione.

The absorption of N-acetylcysteine (NAC) and transport across the cellular membrane is facilitated by the presence of ascorbic acid (vitamin C). Vitamin C maximizes NAC transport across biological cell membranes and helps to conserve existing glutathione stores within the cell cytosol.

The utilization of N-acetylcysteine within the biological cell to synthesize glutathione is improved by the presence of alpha lipoic acid. Alpha lipoic acid increases the cell's ability to make glutathione. It enables the key enzyme required for glutathione synthesis to work under optimum conditions and induces a substantial increase in intracellular reduced glutathione; see Busse E. Zimmer G. Schopohl B, et al. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo; Arzneimittel-Forschung 1992;42:829-831; and Han D. Handelman G. Marcocci, et al. Lipoic Acid Increases de novo Synthesis of Cellular Glutathione by Improving Cystine Utilization, Biofactors 1997;6:321-338. 1995:29: 1263-73.

As mentioned above, support of liver function in the mammal being treated for low glutathione levels is advantageous. For this purpose, there may be orally administered to the mammal the following:

A. Sylimarin serves to improve and restore liver function. It quenches free radicals, reduces potential toxicity, and stimulates protein synthesis necessary to create new liver cells. Also known as "silibin", "silybin" or "silybinin", Silymarin is a generic term for extract from the mature fruits of Silybum marianum (sometimes Carduus marianus), commonly known as milk thistle; see Madaus AG publication: Legalon. Koln, Germany, 1989 and Valenzuela A, et al. Silymarin Protection Against Hepatic Lipin Peroxidation Induced by Acute Ethanol Intoxication in Rats, Biochemical Pharmacology, 1985:34(12):2209-2212. Sylimarin is available under the trade name Legalon.RTM., from Madaus AG, (Jarrow Formulas, Inc.; Madaus, 1989).

B. Quercetin [2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one] is used for its ability to eliminate toxic compounds found in the liver. It has anti-hepatotoxic, antiviral, anti-inflammatory and antibacterial properties. It may be synthesized by the method of Shakhova et al., Zh. Obsheh. Khim., 32, 390 (1962).

Advantageously, the following nutritionals are also employed in the method of the invention.

L-glutamine is an essential dietary component for the support of gastrointestinal growth and function and it is utilized as fuel in the small intestines. It is used by the intestinal tract in large amounts for energy during periods of physiological stress. It has been shown to preserve liver glutathione after lethal hepatic injury and nourish tissues in the GI tract, liver and immune system, see for example; Souba, W.W., et al. The Role of Glutamine in Maintaining a Healthy Gut and Supporting the Metabolic Response to Injury and Infection. J. Of Surgical Res., 990:48(4):83-91.

N-acetyl-d-glucosamine (NAG) is a key precursor in the biosynthesis of mucosal glycoproteins that form glycocalyx. The glycalyx is the most superficial, highly viscous layer of the gut mucosa that comes in contact with intestinal contents. The glycoprotein layer acts to protect the underlying tissues from exposure to enzymes, acid and bacterial assault while providing a selectively absorptive surface, Wilmore, D. W., et al, The gut: a Central Organ After Surgical Stress; Surgery 1988: 104, (5):917-23.

Probiotics or "healthy bacteria" are necessary as they breakdown nutrients, eliminate toxins and inhibit harmful bacteria that enter mammalian systems through the GI tract. The term "Probiotic" is defined herein as "A live microbial food supplement which beneficially affects the host mammal by improving its microbial balance". Representative of healthy bacteria are isolates of bifidobacteria, lactobacilli, such as Lactobacillus acidophilus and Lactobacillus casei, propionibacteria, and enterococci. Lactobacilli are preferred in the composition and method of the invention (see Perdigon, G. et al., Immunology 63:17-23 (1988)). More preferably Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus acidophillus, and Saccharomyces boulardi are used.

Finally, a source of dietary protein is preferred and advantageous to supplement the nutritional needs of the mammal. We have found that the compositions of the invention and the method herein described are optimized by inclusion of a biologically active whey protein composition comprising an undenatured whey protein concentrate obtained from raw mammalian milk. This concentrate contains substantially all of the heat labile whey protein found in the raw milk. Representative of concentrate which are commercially available include Promod.TM., available from Ross Laboratories, Division of Abbott Laboratories, Chicago, Ill. Concentrates may also be prepared by the method described in U.S. Pat. No. 5,290,571, incorporated herein by reference thereto. The undenatured whey protein concentrates also contain a rich variety of immunoglobulins which boast the immunologic response of the mammal treated with the concentrates; see for example U.S. Pat. No. 5,456,924 which is incorporated herein by reference thereto.

A high protein, low fat whey has immuno-supportive properties. It is rich in naturally active immunoglobulins, essential amino acids and other important nutrients critical for proper nutrient utilization within the gut.

We have discovered that the ingredients described above work synergistically to provide the necessary nutrients required for glutathione production while supporting the mammal's ability to produce and preserve existing stores of GSH. The effect of the admixture of ingredients is far more significant than the individual ingredients alone.

This invention also relates also to pharmaceutical dosage unit forms for systemic administration (oral, topical administration) which are useful in treating mammals, including humans. The term "dosage unit form" as used in this specification and in the claims refers to physically discrete units suitable as unitary dosage for mammalian subjects, each unit containing a predetermined quantity of the essential active ingredient; calculated to produce the desired effect in combination with the required pharmaceutical means which adapt said ingredient for systemic administration. Examples of dosage unit forms in accordance with this invention are tablets, capsules, orally administered liquid preparations in liquid vehicles, suppositories, and dry preparations for the extemporaneous preparation of preparations in a liquid vehicle. Solid diluents or carriers for the solid oral pharmaceutical dosage unit forms are selected from the group consisting of lipids, carbohydrates, proteins and mineral solids, for example, starch, sucrose, kaolin, dicalcium phosphate, gelatin, acacia, corn syrup, corn starch, talc and the like. Capsules, both hard and soft, are formulated with conventional diluents and excipients, for example, edible oils, talc, calcium carbonate, calcium stearate, magnesium stearate and the like. Liquid pharmaceutical preparations for oral administration may be prepared in water or aqueous solutions which advantageously contain suspending agents, such as for example, sodium carboxymethylcellulose, methylcellulose, acacia, polyvinyl pyrrolidone, polyvinyl alcohol and the like.

Such preparations must be stable under the conditions of manufacture and storage, and ordinarily contain in addition to the basic solvent or suspending liquid, preservatives in the nature of bactericidal and fungicidal agents, for example, parabens, chlorobutanol, benzyl alcohol, phenol, thimerosal, and the like. In many cases it is preferable to include isotonic agents, for example, sugars or sodium chloride. Carriers and vehicles include vegetable oils, water, ethanol, and polyols, for example, glycerol, propylene glycol, liquid polyethylene glycol, and the like.

The pharmaceutical dosage unit forms are prepared in accordance with the preceding general description to provide an effective amount of the essential active ingredient per dosage unit form in admixture with the means for adaptation to systemic administration. In general, the unit dose form will contain 3 to 73 percent by weight of the essential active ingredient.

It will be appreciated that the exact dosage of the essential active ingredient constituting an effective amount for treatment of a mammal according to the method of the invention will vary greatly depending on the specific nature of the clinical condition being treated, severity of the condition, species of mammal, age, weight and condition of the mammal, mode of administration of the dosage form and the specific formulation being administered. The exact dose required for a given situation may be determined by administration of a trial dose and observation of the clinical response. In general, an effective amount to be administered will be within a range of from about 0.1 mg. per kg. to about 50 mg. per kg. of body weight of the recipient, daily. Preferably 0.5 mg./kg. to about 25 mg./kg. daily is provided. In most instances, a single month of administration will effect a noticeable response and bring about the result desired. In cases such as the treatment of immunological conditions however, it may be desirable to repeat the administrations several times daily over longer periods of time.

The following examples and preparations describe the manner and process of making and using the invention and set forth the best mode contemplated by the inventor of carrying out the invention but are not to be construed as limiting.

EXAMPLE 1

A mixture of the following ingredients is prepared by hand mixing:

Ingredient Quantity N-acetylcysteine 1,000 to 20,000 mg vitamin C 5,000 to 50,000 mg alpha-lipoic acid 100 to 2,500 mg sylmarin 100 to 2,500 mg Quercetin 100 to 2,500 mg l-glutamine 500 to 2,000 mg N-acetyl-d-glucosamine 500 to 2,000 mg whey protein concentrate 1,000 to 20,000 mg Lactobacillus acidophilus Twenty Million to One Billion CFU; Schiff Products, Inc., Salt Lake City, Utah. orange essence flavor Adjust to taste

The mixture which constitutes the essential active ingredient of a preferred embodiment of the invention, together with a flavorant may be compounded into wafers, tablets or capsules containing 750 to 14,000 mg of active ingredient. In an uncompounded form, the powder dry mixture may be orally administered to a human (one teaspoonful, once or twice daily) as a dietary supplement or as recommended by a health care professional. Alternatively, the dry powder may be mixed with juice, water or food to facilitate administration.

EXAMPLE 2

Three dosage units in powder form, each containing 500 mg of essential active ingredient (e.g an amount of the mixture of Example 1, supra. were prepared from the following ingredients:

essential active ingredient 1500 g starch (Rx-1500) 300 g magnesium stearate, USP 39 g colloidal silicic acid 19.5 g Avicel .RTM. pH 102. q.s. to 3900 g

The essential active ingredient was ground through a 0.25 mm sieve opening screen. The powdered active ingredient, with 50% of the total amount of magnesium stearate be used, colloidal silicic acid and Avicel.RTM. pH 10.2 were passed through a 40 mesh sieve, mixed for 20 minutes and then slugged. The slugs were broken down by forcing through a screen No. 11, and mixed with the remaining magnesium stearate.

One dosage given orally 1-4 times a day is useful in the relief of immuno-deficiency in adult humans provoked by infective disease, or other etiological causes.

EXAMPLE 3

Three thousand dosage units for oral use, each containing 750 mg of the essential active ingredient, were prepared from the following ingredients:

essential active ingredient 750 g colloidal silicic acid 30 g magnesium stearate USP 30 g microcrystalline cellulose 150 g lactose 90 g

In accordance with the active ingredient potency, the amount of lactose was adjusted to achieve a weight of 900 mg for each dosage unit. The ingredients were passed through a 40 mesh sieve and mixed for 30 minutes. The powder may be mixed into a drink or inserted into hard gelatin capsules No. 0 and filled using Zanazi, model RV-59 equipment. The capsules should be preserved in airtight, light-resistant containers.

When administered to a human adult suffering from low levels of glutathione (GSH) 1 to 4 dosage units daily, the level is adjusted upward to a normal range.

EXAMPLE 4

A mixture of the following ingredients is formed into a powdered dosage form in the following proportion:

Ingredient Quantity Vitamin C (ascorbate) 1000 mg N-acetyle cysteine 1500 mg L-Glutamine 3000 mg N-acetyle d-glucosamine 500 mg Alpha Lipoic acid (ALA) 75 mg Quercetin 75 mg Sylimarine 100 mg Whey protein 500 mg Conjugated linoteic acid (CLA) 500 mg Orange flavor 380 mg Rice syrup 1516 mg Malic acid 7.8 mg Citric acid 7.8 mg Stevia 455 mg GI Balance (Probiotic) 300 mg

Our studies have shown that the administration of the above dosage unit (one rounded teaspoon) mixed into a liquid 1-4 times (preferably 2 times) a day is useful in the relief of immuno-deficiency in adult humans provoked by infective disease, or other etiological causes. For example, the inventive composition can be used effectively to improve heptatic function e.g. decreased inflamation (ALT) in patients with chronic hepatitis C and patients who are receiving protease inhibitors as part of HAART therapy for HIV. Both groups demonstrated an increase in intra lymphocyte GSH levels after the administration of the inventive composition.

Our studies have shown systemic administration of the composition results in an improvement in T lymphocyte function which correlates directly with an increased intra lymphocyte GSH. In addition, our data demonstrates that the inventive composition and method shifts the T-cell balance from TH2 (allergy producing) to TH1 (viral/tumor killing) and the increases intra lymphocyte GSH correlate directly with decreased levels of IgE the immunoglobulin associated with allergies. Further studies have revealed the following:

Systemic administration of the composition increases natural killer cell function which is considered a primitive first line of cellular immune defense.

Systemic administration of the composition decreases serum cholesterol and triglycerides of between 10 and 20% in patients with a variety of hyperlipidemias and a decrease in myalgias associated with illness and exercise and improved muscle recovery after exercise.

Systemic administration of the composition decreases fatigue in patients suffering from a variety of illnesses including but not limited to chronic viral infections, HIV, hepatitis C, chronic fatigue, immuno deficiency syndrome, immune deficiencies, cancer, B-cell malignancies, including lymphomas, chronic leukemia, myeloma Waldenstrom's and MGUS. This makes the composition function as both a pharmaceutical and a therapeutic substance for patients suffering from the debilitating conditions.

Initial studies have shown that the systemic administration of the inventive composition also increases energy in people without illness who are exposed to increased stress.

As such, the combination formulated will improve hepatic function in conditions associated with chronic viral infections, as well as any condition associated with increased hepatic work or stress.

Thus by the present invention its advantages will be realized and although preferred embodiments have been disclosed and described in detail herein, its scope should not be limited thereby rather its scope should be determined by that of the appended claims.
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MaxGXL™ Supplement Facts.......Serving Size 3 Capsules.......56 Servings Per Box.......Vitamin C (as Calcium Ascorbate) 250 mg.......N Acetyl Cysteine 375 mg.......L-glutamine 750 mg.......N Acetyl D-Glucosamine 125 mg.......Quercetin 37.5 mg.......Milk Thistle Extract 25 mg.......Alpha Lipoic Acid 75 mg.......Cordyceps 300 mg.......Conjugated Linoleic Acid 100 mg.......Other Ingredients: Gelatin Capsules........

Cost of MaxGXL™ is 75.95 for a 4 week supply on autoship........ Please call (702)-334-1426 and leave your name and number and best time for me to return your call to start your monthly autoship of MaxGXL's™......... If you prefer you may email studiorich@aol.com Please leave your name, address, city, state, zipcode, email, telephone number, charge card number and expiration. And you will be billed 75.95 each month, and you will recieve a 4 week supply every month, that will be mailed to you. Shipping cost is included in the 75.95 price.........Write me the above information, and mail to: Richard Adkins 10512 Snyder Ave. Las Vegas, NV 89134 or click this link to learn more, or to order: http://www.maxgxl.com/radkins